HbA1c Diagnostic Categories and -Cell Function Relative to Insulin Sensitivity in Overweight/Obese Adolescents
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چکیده
منابع مشابه
HbA1c Diagnostic Categories and β-Cell Function Relative to Insulin Sensitivity in Overweight/Obese Adolescents
OBJECTIVE The recommended HbA(1c) diagnostic categories remain controversial and their utility in doubt in pediatrics. We hypothesized that alterations in the pathophysiologic mechanisms of type 2 diabetes may be evident in the American Diabetes Association recommended at-risk/prediabetes category (HbA(1c) 5.7 to <6.5%). RESEARCH DESIGN AND METHODS We compared in vivo hepatic and peripheral i...
متن کاملMeasuring β-Cell Function Relative to Insulin Sensitivity in Youth
OBJECTIVE To compare β-cell function relative to insulin sensitivity, disposition index (DI), calculated from two clamps (2cDI, insulin sensitivity from the hyperinsulinemic-euglycemic clamp and first-phase insulin from the hyperglycemic clamp) with the DI calculated from the hyperglycemic clamp alone (hcDI). RESEARCH DESIGN AND METHODS Complete data from hyperglycemic and hyperinsulinemic-eu...
متن کاملMeasuring b-Cell Function Relative to Insulin Sensitivity in Youth Does the hyperglycemic clamp suffice?
RESEARCH DESIGN AND METHODSdComplete data from hyperglycemic and hyperinsulinemic-euglycemic clamps were available for 330 youth, including 73 normal weight (NW), 168 obese with normal glucose tolerance (OB-NGT), 57 obese with impaired glucose tolerance (OB-IGT), and 32 obese with type 2 diabetes (OB-T2DM). The correlation between hcDI and 2cDI and Bland-Altman analysis of agreement between the...
متن کامل25-Hydroxyvitamin D Concentrations and In Vivo Insulin Sensitivity and β-Cell Function Relative to Insulin Sensitivity in Black and White Youth
OBJECTIVE To examine the relationships between plasma 25-hydroxyvitamin D [25(OH)D] and in vivo insulin sensitivity and β-cell function relative to insulin sensitivity, disposition index (DI), in black and white youth. RESEARCH DESIGN AND METHODS Plasma 25(OH)D concentrations were analyzed in banked specimens in healthy youth aged 8 to 18 years who had existing data on hyperinsulinemic-euglyc...
متن کامل25-Hydroxyvitamin D concentrations and in vivo insulin sensitivity and β-cell function relative to insulin sensitivity in black and white youth. Diabetes Care 2012;35:627–633
D concentrations and in vivo insulin sensitivity and b-cell function relative to insulin sensitivity in black and white youth. In the print version of the article listed above, in the " Biochemical Measurements " section, the sentence " The intrassay and interassay coefficients of variation were 8 ng/mL and 10 ng/mL, respectively " should read as follows: " The intraassay and interassay coeffic...
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ژورنال
عنوان ژورنال: Diabetes Care
سال: 2012
ISSN: 0149-5992,1935-5548
DOI: 10.2337/dc12-0747